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One of the most famous Spanish explorers of 16th century was Hernando de Soto, who accompanied conquistador Francisco Pizarro in his destruction of Incan empire and contributed to the modern history by exploring the lands of Florida and discovering the mighty river Mississippi.
Knowledge of 16th century Caribbean island Cuba (then known as Hispaniola) expanded greatly with the discoveries of Spanish captain Sebastián de Ocampo who successfully managed to circumvent this island for the first time and enter the gulf of Mexico.
Pedro de Alvarado is today remembered as one of the most important Spanish conquistadors who was involved in several military campaigns in Central America, including Mexico, Guatemala, Honduras, El Salvador and the downfall of the Aztec culture.
Francisco Vasquez de Coronado is today remembered as one of the pioneers of exploration of mexico and southeastern United States. During the one of his exploration in mid-16th century he searched for mystical El-Dorado, mapping the large areas of today’s northern Mexico and New Mexico.